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KMID : 1123920050190010204
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 1 p.204 ~ p.211
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Anti-inflammatory Effect of Bear’s Gall in Rat Microglia
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Joo Seong-Soo
Yoo Yeong-Min
Lee Seon-Goo
Lee Do-Ik
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Abstract
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We hypothesize that bear’s gall may have a certain role in anti-inflammation through a preventive effect of pro-inflammatory potentials. Secondly, we tried to connect the experimental results to Alzheimer’s disease (AD), which chronic inflammation is a main cause of the disease. For this theme, we designed to elucidate the efficacy of bear’s gall in suppressing the pro-inflammatory mediators, such as nitric oxide (NO) and in rat microglia. From the study, we concluded that bear’s gall plays a positive role in suppressing such pro-inflammatory repertoire from rat microglia comparing to normal and positive control, such as culture media and cyclosporine. Interestingly, bear’s gall showed a prolonged effect of anti-inflammation comparing with cyclosporine when time goes by up to 48h with a significant suppression at . Therefore, we can consider that bear’s gall in part can be applied to AD therapy in that it suppresses the expression of pro-inflammatory mediators as well as its continued effect.
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KEYWORD
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microglia, bear’s gall, Alzheimer’s disease, Nitric Oxide
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